Cardiac Sensitization

If vapors are inhaled at a concentration of 105,000 ppm and higher, the heart may become sensitized to adrenaline, leading to cardiac irregularities and, possibly, cardiac arrest. Similar effects are observed with many hydrocarbons and halocarbons at high concentrations. The likelihood of these cardiac problems increases if the person is under physical or emotional stress.

Because of possible disturbances of cardiac rhythm, catecholamine drugs, such as epinephrine, should be considered only as a last resort in life-threatening emergencies.

The threshold cardiac sensitization, lowest observed adverse effect level (LOAEL) for FM-200® is 105,000 ppm (10.5%) and the no observed adverse effect level (NOAEL) is 90,000 ppm (9%) as determined in epinephrine-challenged dogs.